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Article

Altered production of penicillin-binding protein 2a can affect phenotypic expression of methicillin resistance in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Nov 1994

Hackbarth C J, Miick C, Chambers H F

Abstract excerpt

Altered production of penicillin-binding protein 2a (PBP 2a) may affect the phenotypic expression of resistance in methicillin-resistant Staphylococcus aureus (MRSA). COL, an MRSA strain that constitutively produces PBP 2a, was transformed with a recombinant plasmid containing the two beta-lactamase regulatory genes, blaI and blaR1, with either the beta-lactamase gene, blaZ, or a truncated blaZ. Both of the...

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Identifiers

PMID: 7872749
DOI: 10.1128/AAC.38.11.2568
PMCID: PMC188243

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