Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ex vivo expansion does not alter the capacity of umbilical cord blood CD34+ cells to generate functional T lymphocytes and dendritic cells.

Stem cells (Dayton, Ohio) - 1 Sept 2006

Kobari Ladan, Giarratana Marie C, Gluckman Jean C, Douay Luc, Rosenzwajg Michelle

Abstract excerpt

We examined whether ex vivo expansion of umbilical cord blood progenitor cells affected their capacity to generate immune cells such as T lymphocytes (TLs) and dendritic cells (DCs). The capacity to generate TLs from cord blood CD34(+) cells expanded for 14 days (d14) was compared with that of nonexpanded CD34(+) cells (d0) using fetal thymus organ cultures or transfer into nonobese diabetic/severe combined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Blood

Share to Interferon-gamma

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Organ Culture Techniques

Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 16946001
DOI: 10.1634/stemcells.2006-0102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ex vivo expansion does not alter the capacity of umbilical cord blood CD34+ cells to generate functional T lymphocytes and dendritic cells.PMID 16946001Read ↗

Umbilical cord blood progeny cells that retain a CD34+ phenotype after ex vivo expansion have less engraftment potential than unexpanded CD34+ cells.Semantic proximity Read ↗

Cord blood CD34+ cells cultured with FLT3L, stem cell factor, interleukin-6, and IL-3 produce CD11c+CD1a-/c- myeloid dendritic cells.Semantic proximity Read ↗

Differential long-term and multilineage engraftment potential from subfractions of human CD34 + cord blood cells transplanted into NOD/SCID miceSemantic proximity Read ↗

Myeloid differentiation of human cord blood CD34+ cells during ex vivo expansion using thrombopoietin, flt3-ligand and/or granulocyte-colony stimulating factor.Semantic proximity Read ↗

Identification of a Novel Subpopulation of Human Cord Blood CD34−CD133−CD7−CD45+Lineage− Cells Capable of Lymphoid/NK Cell Differentiation After In Vitro Exposure to IL-15Semantic proximity Read ↗

The relative merits of cord blood as a cell source for autologous T regulatory cell therapy in type 1 diabetes.Semantic proximity Read ↗

Quantitative Analysis Reveals Expansion of Human Hematopoietic Repopulating Cells After Short-term Ex Vivo CultureSemantic proximity Read ↗

Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood.Semantic proximity Read ↗

Extensive and long-term ex vivo production of dendritic cells from CD34 positive umbilical cord blood or bone marrow cells by novel culture system using mouse stroma.Semantic proximity Read ↗

Dendritic Cells Differentiated from Human Umbilical Cord Blood-Derived Monocytes Exhibit Tolerogenic Characteristics.Semantic proximity Read ↗

Flt3L enhances the early stem cell compartment after ex vivo amplification of umbilical cord blood CD34+ cells.Semantic proximity Read ↗

Induction of langerin+ Langerhans cell-like cells expressing reduced TLR3 from CD34+ cord blood cells stimulated with GM-CSF, TGF-β1, and TNF-α.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.