Differential long-term and multilineage engraftment potential from subfractions of human CD34 + cord blood cells transplanted into NOD/SCID mice

Abstract excerpt

Over the past decade xenotransplantation systems have been used with increasing success to gain a better understanding of human cells that are able to initiate and maintain the hematopoietic system in vivo. The nonobese diabetic/severe combined immunodeficiency (SCID) mouse has been a particularly useful model. Human cells capable of hematopoietic repopulation in this mouse, termed SCID-repopulating cells, have...

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