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The Metallothionein/Thionein System: An Oxidoreductive Metabolic Zinc Link

18 Dec 2008

Abstract excerpt

Metallothioneins (MTs) were discovered more than 50 years ago and identified as low-molecular weight, sulfhydryl-rich proteins that were subsequently found to bind zinc predominantly. The binding of seemingly redox inactive zinc ions allows MT to play a central role in oxidoreductive cellular metabolism, cellular zinc distribution and homeostasis. In this interpretive study, we discuss the interaction of MT with...

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PMID: 19089881
DOI: 10.1002/cbic.200800511

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