Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of vaccinia virus temperature-sensitive I7L mutants reveals two potential functional domains.

Virology journal - 31 Aug 2006

Moerdyk Megan J, Byrd Chelsea M, Hruby Dennis E

Abstract excerpt

As an approach to initiating a structure-function analysis of the vaccinia virus I7L core protein proteinase, a collection of conditional-lethal mutants in which the mutation had been mapped to the I7L locus were subjected to genomic sequencing and phenotypic analyses. Mutations in six vaccinia v...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Catalytic Domain
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Open Reading Frames

Share to Peptide Hydrolases

Share to Temperature

Share to Vaccinia virus

Share to Viral Core Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16945137
DOI: 10.1186/1743-422X-3-64
PMCID: PMC1570340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16945137-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of vaccinia virus temperature-sensitive I7L mutants reveals two potential functional domains.PMID 16945137Read ↗

A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis.Semantic proximity Read ↗

Unique temperature-sensitive defect in vaccinia virus morphogenesis maps to a single nucleotide substitution in the A30L gene.Semantic proximity Read ↗

Vaccinia virus mutants with alanine substitutions in the conserved G5R gene fail to initiate morphogenesis at the nonpermissive temperature.Semantic proximity Read ↗

Genetic and cell biological characterization of the vaccinia virus A30 and G7 phosphoproteins.Semantic proximity Read ↗

Involvement of spicules in the formation of vaccinia virus envelopes elucidated by a conditional lethal mutant.Semantic proximity Read ↗

The vaccinia virus E8R gene product is required for formation of transcriptionally active virions.Semantic proximity Read ↗

Analysis of the role of vaccinia virus H7 in virion membrane biogenesis with an H7-deletion mutant.Semantic proximity Read ↗

Vaccinia virus morphogenesis is blocked by temperature-sensitive mutations in the F10 gene, which encodes protein kinase 2.Semantic proximity Read ↗

Temperature-sensitive mutants with lesions in the vaccinia virus F10 kinase undergo arrest at the earliest stage of virion morphogenesis.Semantic proximity Read ↗

Temperature-sensitive mutants in the vaccinia virus 4b virion structural protein assemble malformed, transcriptionally inactive intracellular mature virions.Semantic proximity Read ↗

Vaccinia virus morphogenesis: a13 phosphoprotein is required for assembly of mature virions.Semantic proximity Read ↗

Clustered charge-to-alanine mutagenesis of the vaccinia virus H5 gene: isolation of a dominant, temperature-sensitive mutant with a profound defect in morphogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.