Article
ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.
Molecular and cellular biology - 1 Sept 2006
Chen Chun, Huang Xiaozhu, Sheppard Dean
Abstract excerpt
A disintegrin and metalloprotease 33 (ADAM33) is a transmembrane protease and integrin ligand that has been identified as an asthma susceptibility gene product. To determine whether ADAM33 plays important roles in mammalian development and the modulation of allergic airway dysfunction, we generated ADAM33-null mice by gene targeting. ADAM33-null mice were born at expected Mendelian ratios, and both male and...
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