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Article

Heterologous AdpA transcription factors enhance landomycin production in Streptomyces cyanogenus S136 under a broad range of growth conditions.

Applied microbiology and biotechnology - 1 Oct 2018

Yushchuk Oleksandr, Ostash Iryna, Vlasiuk Iryna, Gren Tetiana, Luzhetskyy Andriy, Kalinowski Joern, Fedorenko Victor, Ostash Bohdan

Abstract excerpt

Streptomyces cyanogenus S136 is the only known producer of landomycin A (LaA), one of the largest glycosylated angucycline antibiotics possessing strong antiproliferative properties. There is rising interest in elucidation of mechanisms of action of landomycins, which, in turn, requires access to large quantities of the pure compounds. Overproduction of LaA has been achieved in the past through manipulation of...

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PMID: 30056513
DOI: 10.1007/s00253-018-9249-1

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