Evidence that Plasmodium falciparum chromosome end clusters are cross‐linked by protein and are the sites of both virulence gene silencing and activation

Abstract excerpt

The malaria parasite Plasmodium falciparum undergoes antigenic variation through allelic exclusion and variant expression of surface proteins encoded by the var gene family. Regulation of var genes is under epigenetic control and involves reversible silencing and activation that requires the physical repositioning of a var locus into a transcriptionally permissive zone of the nuclear periphery. P. falciparum...

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