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Article

Epigenetics and chromatin structure regulate var2csa expression and the placental-binding phenotype in Plasmodium falciparum.

eLife - 15 Apr 2026

Lenz Todd, Sirel Madle, Hoppe Hannes, Shafeeq Sulman, Le Roch Karine G, Ribacke Ulf

Abstract excerpt

Plasmodium falciparum is responsible for what appears to be a never-ending public health issue in the developing world. With repeated infections, a gradual semi-immunity to severe malaria can be acquired, but this is disrupted when women become pregnant as the parasite cytoadheres in the placenta to prevent splenic clearance. This change in tissue tropism is due to specific transcription of the antigenically...

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Share to Antigens, Protozoan
Share to Chromatin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41984626
DOI: 10.7554/eLife.93632
PMCID: PMC13082790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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