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Article

Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors.

PLoS pathogens - 1 Sept 2009

Flueck Christian, Bartfai Richard, Volz Jennifer, Niederwieser Igor, Salcedo-Amaya Adriana M, Alako Blaise T F, Ehlgen Florian, Ralph Stuart A, Cowman Alan F, Bozdech Zbynek, Stunnenberg Hendrik G, Voss Till S

Abstract excerpt

Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune responses. Antigenic variation of PfEMP1 occurs through in situ switches in mono-allelic var gene transcription, which is PfSIR2-dependent and associated with the presence of...

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Identifiers

PMID: 19730695
DOI: 10.1371/journal.ppat.1000569
PMCID: PMC2731224

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