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Article

Plasmodium falciparum var gene silencing is determined by cis DNA elements that form stable and heritable interactions.

Eukaryotic cell - 1 Apr 2011

Swamy Lakshmi, Amulic Borko, Deitsch Kirk W

Abstract excerpt

Antigenic variation in the human malaria parasite Plasmodium falciparum depends on the transcriptional regulation of the var gene family. In each individual parasite, mRNA is expressed exclusively from 1 var gene out of ∼60, while the rest of the genes are transcriptionally silenced. Both modifications to chromatin structure and DNA regulatory elements associated with each var gene have been implicated in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21317310
DOI: 10.1128/EC.00329-10
PMCID: PMC3127639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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