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Article

A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria.

Nature - 23 Feb 2006

Voss Till S, Healer Julie, Marty Allison J, Duffy Michael F, Thompson Jennifer K, Beeson James G, Reeder John C, Crabb Brendan S, Cowman Alan F

Abstract excerpt

Mono-allelic expression of gene families is used by many organisms to mediate phenotypic variation of surface proteins. In the apicomplexan parasite Plasmodium falciparum, responsible for the severe form of malaria in humans, this is exemplified by antigenic variation of the highly polymorphic P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1, encoded by the 60-member var gene family, represents a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16382237
DOI: 10.1038/nature04407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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