Alterations in local chromatin environment are involved in silencing and activation of subtelomeric <i>var</i> genes in <i>Plasmodium falciparum</i>

Abstract excerpt

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by the var gene family, undergoes antigenic variation and plays an important role in chronic infection and severe malaria. Only a single var gene is transcribed per parasite, and epigenetic control mechanisms are fundamental in this strategy of mutually exclusive transcription. We show that subtelomeric upsB var gene promoters carried on...

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