Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2005

Eaton Allison M, Sandler Robert, Carethers John M, Millikan Robert C, Galanko Joseph, Keku Temitope O

Abstract excerpt

The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene plays a critical role in folate metabolism. Studies on the association between MTHFR polymorphisms and length changes in short tandem repeat DNA sequences [microsatellite instability (MSI)] are inconsistent. Using data from colon cancer cases (n=503) enrolled as part of an existing population-based case-control study, we investigated the association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Folic Acid

Share to Genotype

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Microsatellite Repeats

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 16103455
DOI: 10.1158/1055-9965.EPI-05-0131
PMCID: PMC4540476

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer.PMID 16103455Read ↗

Dietary intake and microsatellite instability in colon tumorsSemantic proximity Read ↗

5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites.Semantic proximity Read ↗

MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients.Semantic proximity Read ↗

Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors.Semantic proximity Read ↗

Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers.Semantic proximity Read ↗

MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer.Semantic proximity Read ↗

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.Semantic proximity Read ↗

A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability.Semantic proximity Read ↗

Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.Semantic proximity Read ↗

Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction?Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.Semantic proximity Read ↗

MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.