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Article

Importance of serine 200 for functional activities of the hemagglutinin-neuraminidase protein of Newcastle Disease Virus.

International journal of oncology - 1 Mar 2004

Fournier Philippe, Zeng Jinyang, Von Der Lieth Claus-W, Washburn Birgit, Ahlert Thorsten, Schirrmacher Volker

Abstract excerpt

Newcastle disease virus (NDV) is an avian paramyxovirus with replication competence in human tumor cells and interesting anti-neoplastic and immune stimulatory properties. In order to increase tumor selectivity of replication, we prepared mutants from the avirulent strain Ulster with monocyclic replication cycle and adapted them for multicyclic replication in human melanoma cells. Two mutants (M1 and M2) showed...

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PMID: 14767547

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