Article
Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase.
Nature structural biology - 1 Nov 2000
Crennell S, Takimoto T, Portner A, Taylor G
Abstract excerpt
Paramyxoviruses are the main cause of respiratory disease in children. One of two viral surface glycoproteins, the hemagglutinin-neuraminidase (HN), has several functions in addition to being the major surface antigen that induces neutralizing antibodies. Here we present the crystal structures of...
Topics
- Amino Acid Sequence
- Binding Sites
- Crystallography, X-Ray
- HN Protein
- Hydrogen-Ion Concentration
- Hydrolysis
- Lactose
- Ligands
- Models, Molecular
- Molecular Sequence Data
- Multienzyme Complexes
- Mutation
- N-Acetylneuraminic Acid
- Newcastle disease virus
- Protein Structure, Quaternary
- Receptors, Virus
- Sequence Alignment
- Sialic Acids