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Article

Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase.

Nature structural biology - 1 Nov 2000

Crennell S, Takimoto T, Portner A, Taylor G

Abstract excerpt

Paramyxoviruses are the main cause of respiratory disease in children. One of two viral surface glycoproteins, the hemagglutinin-neuraminidase (HN), has several functions in addition to being the major surface antigen that induces neutralizing antibodies. Here we present the crystal structures of Newcastle disease virus HN alone and in complex with either an inhibitor or with the beta-anomer of sialic acid. The...

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PMID: 11062565
DOI: 10.1038/81002

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