Article
Alphavirus capsid protein helix I controls a checkpoint in nucleocapsid core assembly.
Journal of virology - 1 Sept 2006
Hong Eunmee M, Perera Rushika, Kuhn Richard J
Abstract excerpt
The assembly of the alphavirus nucleocapsid core has been investigated using an in vitro assembly system. The C-terminal two-thirds of capsid protein (CP), residues 81 to 264 in Sindbis virus (SINV), have been previously shown to have all the RNA-CP and CP-CP contacts required for core assembly in vitro. Helix I, which is located in the N-terminal dispensable region of the CP, has been proposed to stabilize the...
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