Alphavirus capsid protein helix I controls a checkpoint in nucleocapsid core assembly.

doi:10.1128/JVI.00619-06

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Article

Alphavirus capsid protein helix I controls a checkpoint in nucleocapsid core assembly.

Journal of virology - 1 Sept 2006

Hong Eunmee M, Perera Rushika, Kuhn Richard J

Abstract excerpt

The assembly of the alphavirus nucleocapsid core has been investigated using an in vitro assembly system. The C-terminal two-thirds of capsid protein (CP), residues 81 to 264 in Sindbis virus (SINV), have been previously shown to have all the RNA-CP and CP-CP contacts required for core assembly in vitro. Helix I, which is located in the N-terminal dispensable region of the CP, has been proposed to stabilize the...

Topics

Alphavirus
Amino Acid Sequence
Capsid Proteins
Cross-Linking Reagents
Dimerization
Molecular Sequence Data
Mutation
Nucleocapsid
Phenotype
Protein Structure, Tertiary
Recombinant Proteins
Ross River virus
Sequence Homology, Amino Acid
Sindbis Virus
Virus Assembly

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Identifiers

PMID: 16940497
DOI: 10.1128/JVI.00619-06
PMCID: PMC1563918

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