Article
Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development.
Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2006
Nadauld Lincoln D, Chidester Stephanie, Shelton Dawne N, Rai Kunal, Broadbent Talmage, Sandoval Imelda T, Peterson Peter W, Manos Elizabeth J, Ireland Chris M, Yost H Joseph, Jones David A
Abstract excerpt
Congenital hypertrophy/hyperplasia of the retinal pigmented epithelium is an ocular lesion found in patients harboring mutations in the adenomatous polyposis coli (APC) tumor suppressor gene. We report that Apc-deficient zebrafish display developmental abnormalities of both the lens and retina. Injection of dominant-negative Lef reduced Wnt signaling in the lens but did not rescue retinal differentiation defects....
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