Four major antigenic sites of the coronavirus transmissible gastroenteritis virus are located on the amino-terminal half of spike glycoprotein S.

Abstract excerpt

Four major antigenic sites have been delineated on the spike protein (S) of the porcine enteric coronavirus transmissible gastroenteritis virus (TGEV) in previous topological studies using monoclonal antibodies (MAbs). Correlation of these sites with the physical structure of the protein was achieved by use of different approaches. Recombinant pEX plasmids directing the synthesis of various fused S polypeptides...

Topics

• Amino Acid Sequence
• Antigens, Viral
• Base Sequence
• Coronaviridae
• DNA
• Epitopes
• Gene Library
• Molecular Sequence Data
• Mutation
• Neutralization Tests
• RNA, Viral