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Assembly of coronavirus spike protein into trimers and its role in epitope expression

1 Nov 1990

Abstract excerpt

The folding and oligomerization of coronavirus spike protein were explored using a panel of monoclonal antibodies. Chemical cross-linking and sedimentation experiments showed that the spike of transmissible gastroenteritis virus is a homotrimer of the S membrane glycoprotein. The spike protein was synthesized as a 175,000-apparent-molecular-weight (175K) monomer subunit that is sensitive to...

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PMID: 2170676
DOI: 10.1128/jvi.64.11.5367-5375.1990

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