Article
Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.
Virology - 1 Jul 1991
Gebauer F, Posthumus W P, Correa I, Suñé C, Smerdou C, Sánchez C M, Lenstra J A, Meloen R H, Enjuanes L
Abstract excerpt
The S glycoprotein of transmissible gastroenteritis virus (TGEV) has been shown to contain four major antigenic sites (A, B, C, and D). Site A is the main inducer of neutralizing antibodies and has been previously subdivided into the three subsites Aa, Ab, and Ac. The residues that contribute to these sites were localized by sequence analysis of 21 mutants that escaped neutralization or binding by TGEV-specific...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antigens, Viral
- Base Sequence
- Cells, Cultured
- DNA, Viral
- Epitopes
- Glycosylation
- Molecular Sequence Data
- Mutation