Article
Structural analysis of the conformational domains involved in neutralization of bovine coronavirus using deletion mutants of the spike glycoprotein S1 subunit expressed by recombinant baculoviruses.
Virology - 1 Jul 1991
Yoo D W, Parker M D, Song J, Cox G J, Deregt D, Babiuk L A
Abstract excerpt
Two conformation-dependent neutralizing epitopes, A and B, have been mapped to the S1 subunit of the S spike glycoprotein of bovine coronavirus (BCV). In order to characterize the structure of these antigenic sites, we constructed a series of cDNA clones encoding deleted or truncated S1 derivativ...
Topics
- Animals
- Antigens, Viral
- Baculoviridae
- Binding Sites
- Cattle
- Chromosome Deletion
- Coronaviridae
- Glycosylation
- Membrane Glycoproteins
- Moths
- Mutation
- Neutralization Tests
- Polymorphism, Genetic
- Protein Conformation