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Article

Retrovirus-mediated gene transfer into CD4+ and CD8+ human T cell subsets derived from tumor-infiltrating lymphocytes and peripheral blood mononuclear cells.

Cancer immunology, immunotherapy : CII - 1 Jan 1991

Morecki S, Karson E, Cornetta K, Kasid A, Aebersold P, Blaese R M, Anderson W F, Rosenberg S A

Abstract excerpt

Studies were undertaken to test the susceptibility of individual T cell subpopulations to retroviral-mediated gene transduction. Gene transfer into human tumor-infiltrating lymphocytes (TIL) or peripheral blood mononuclear cells (PBMC) was carried out by transduction with an amphotropic murine retroviral vector (LNL6 or N2) containing the bacterial neoR gene. The presence of the neoR gene in the TIL population...

Topics

Blotting, Southern
Cell Division
Cell Survival
Cells, Cultured
DNA
Genes, Bacterial
Genetic Markers
Gentamicins
Humans
Interleukin-2
Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes, Tumor-Infiltrating

Phenotype

Retroviridae

Transduction, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2007247
DOI: 10.1007/BF01741329
PMCID: PMC11038738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2007247-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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