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Article

Differentiation arrest by hypoxia.

The Journal of biological chemistry - 13 Oct 2006

Lin Qun, Lee Yi-Jang, Yun Zhong

Abstract excerpt

The stem cell niche is a unique tissue microenvironment that regulates the self-renewal and differentiation of stem cells. Although several stromal cells and molecular pathways have been identified, the microenvironment of the stem cell niche remains largely unclear. Recent evidence suggests that stem cells are localized in areas with low oxygen. We have hypothesized that hypoxia maintains the undifferentiated...

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Share to 3T3-L1 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

Identifiers

PMID: 16926163
DOI: 10.1074/jbc.C600120200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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