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Article

Characterization of the Rhesus Cytomegalovirus US28 Locus

11 Sept 2003

Abstract excerpt

Human cytomegalovirus (CMV) US28 (and the related open reading frame [ORF] US27) are G-protein-coupled receptor homologs believed to play a role in viral pathogenesis. In vitro, US28 has been shown to bind and internalize ligands, as well as activate intracellular signaling in response to certain chemokines, and to initiate the migration of smooth muscle cells to chemokine gradients. To assess the role of US28 in...

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PMID: 12970425
DOI: 10.1128/jvi.77.19.10404-10413.2003

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