Article
A drug-resistant mutation in plant target of rapamycin validates the specificity of ATP-competitive TOR inhibitors in vivo.
The Plant journal : for cell and molecular biology - 1 Mar 2024
Perdoux Romain, Barrada Adam, Boulaiz Manal, Garau Camille, Belbachir Clément, Lecampion Cécile, Montané Marie-Hélène, Menand Benoît
Abstract excerpt
Kinases are major components of cellular signaling pathways, regulating key cellular activities through phosphorylation. Kinase inhibitors are efficient tools for studying kinase targets and functions, however assessing their kinase specificity in vivo is essential. The identification of resistant kinase mutants has been proposed to be the most convincing approach to achieve this goal. Here, we address this issue...
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