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Article

Specific Contribution of p19ARF to Nitric Oxide-Dependent Apoptosis

1 Sept 2006

Abstract excerpt

NO is an important bioactive molecule involved in a variety of physio- and pathological processes, including apoptosis induction. The proapoptotic activity of NO involves the rise in the tumor suppressor p53 and the accumulation and targeting of proapoptotic members of the Bcl-2 family, in particular Bax and the release of cytochrome c from the mitochondria. However, the exact mechanism by which NO induces p53...

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PMID: 16920973
DOI: 10.4049/jimmunol.177.5.3327

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