Article
The yeast aquaglyceroporin Fps1p is a bidirectional arsenite channel.
FEBS letters - 19 Feb 2010
Maciaszczyk-Dziubinska Ewa, Migdal Iwona, Migocka Magdalena, Bocer Tomasz, Wysocki Robert
Abstract excerpt
The stress-activated kinase Hog1p mediates arsenic tolerance by decreasing arsenite influx through the aquaglyceroporin Fps1p in Saccharomyces cerevisiae. Unexpectedly, we found that overexpression of FPS1 increased arsenite tolerance suggesting a physiological role of Fps1p in arsenic detoxification. Consistently, during arsenite treatment transcription of FPS1 gene was strongly upregulated, while Fps1p was not...
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