Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors.

Oncogene - 25 Nov 2004

Sakamoto Naoto, Terai Takeshi, Ajioka Yoichi, Abe Satoshi, Kobayasi Osamu, Hirai Shu, Hino Okio, Watanabe Hidenobu, Sato Nobuhiro, Shimoda Tadakazu, Fujii Hiroaki

Abstract excerpt

Flat colorectal tumors, characterized by high-grade dysplasia from early small flat mucosal lesions, exhibit a relatively aggressive clinical behavior and are known for their infrequent K-ras mutations. In this study, we investigated the methylation status of the RASSF1A promoter in association w...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 3
Share to Colon
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Loss of Heterozygosity

Share to Mucous Membrane

Share to Polymorphism, Single-Stranded Conformational

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 15480433
DOI: 10.1038/sj.onc.1207993

Genes

RASSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15480433-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors.PMID 15480433Read ↗

Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.Semantic proximity Read ↗

Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancersSemantic proximity Read ↗

Aberrant DNA methylation profiles of inherited and sporadic colorectal cancerSemantic proximity Read ↗

CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations.Semantic proximity Read ↗

Comprehensive DNA Methylation Analysis Reveals a Common Ten-Gene Methylation Signature in Colorectal Adenomas and Carcinomas.Semantic proximity Read ↗

Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal CarcinogenesisSemantic proximity Read ↗

Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.Semantic proximity Read ↗

Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers.Semantic proximity Read ↗

DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomasSemantic proximity Read ↗

K-ras mutations and RASSF1A promoter methylation in colorectal cancer.Semantic proximity Read ↗

A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal CancerSemantic proximity Read ↗

Epigenetic alterations in RASSF1A in human aberrant crypt foci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.