Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent.

The EMBO journal - 1 May 1990

Ricchetti M, Buc H

Abstract excerpt

Kinetics of incorporation of correct and incorrect deoxynucleotides by three reverse transcriptases have been followed, by gel assay, on a series of DNA templates, including part of the HIV-1 gag DNA minus strand. Insertion kinetics for the properly matched nucleotide at a given place on the template vary strongly from one enzyme to the next. No significant correlation is found between the site-specific Michaelis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Replication
Share to DNA, Viral
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Kinetics

Share to Molecular Sequence Data

Share to RNA-Directed DNA Polymerase

Source

Open in PubMed Open full text

Identifiers

PMID: 1691709
DOI: 10.1002/j.1460-2075.1990.tb08278.x
PMCID: PMC551854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent.PMID 1691709Read ↗

Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates.Semantic proximity Read ↗

The base substitution fidelity of HIV-1 reverse transcriptase on DNA and RNA templates probed with 8-oxo-deoxyguanosine triphosphate.Semantic proximity Read ↗

Comparison of HIV-1 and avian myeloblastosis virus reverse transcriptase fidelity on RNA and DNA templates.Semantic proximity Read ↗

Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases.Semantic proximity Read ↗

Fidelity of HIV-1 reverse transcriptase copying RNA in vitro.Semantic proximity Read ↗

Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase.Semantic proximity Read ↗

The fidelity of misinsertion and mispair extension throughout DNA synthesis exhibited by mutants of the reverse transcriptase of human immunodeficiency virus type 2 resistant to nucleoside analogs.Semantic proximity Read ↗

The cost of replication fidelity in human immunodeficiency virus type 1.Semantic proximity Read ↗

Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.Semantic proximity Read ↗

The fidelity of 3' misinsertion and mispair extension during DNA synthesis exhibited by two drug-resistant mutants of the reverse transcriptase of human immunodeficiency virus type 1 with Leu74-->Val and Glu89-->Gly.Semantic proximity Read ↗

Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene.Semantic proximity Read ↗

Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.