Article
The fidelity of 3' misinsertion and mispair extension during DNA synthesis exhibited by two drug-resistant mutants of the reverse transcriptase of human immunodeficiency virus type 1 with Leu74-->Val and Glu89-->Gly.
European journal of biochemistry - 1 Jul 1997
Rubinek T, Bakhanashvili M, Taube R, Avidan O, Hizi A
Abstract excerpt
The relatively low fidelity of DNA synthesis characteristic to the reverse transcriptases (RTs) of the AIDS-causing viruses, human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2, respectively) was implicated as a dominant factor that contributes to the genetic hypervariability of these v...
Topics
- DNA
- Drug Resistance
- HIV Reverse Transcriptase
- HIV-1
- Mutation
- Structure-Activity Relationship