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Article

Functional analysis of the LXXLL motifs of the human glucocorticoid receptor: association with altered ligand affinity.

The Journal of steroid biochemistry and molecular biology - 1 Oct 2006

Dong Diane D, Jewell Christine M, Bienstock Rachelle J, Cidlowski John A

Abstract excerpt

Although LXXLL motifs in coactivators mediate binding to liganded nuclear receptors, the roles of comparable motifs within nuclear receptors are less understood. We investigated the role of the LXXLL motifs in the human glucocorticoid receptor both in transcriptional activation and repression of gene expression. The two conserved LXXLL motifs within the ligand binding domain of the receptor, amino acids 532-536...

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PMID: 16914312
DOI: 10.1016/j.jsbmb.2006.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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