Article
Impact of genetic variants in IL-4, IL-4 RA and IL-13 on the anti-pneumococcal antibody response.
Vaccine - 4 Jan 2007
Wiertsema Selma P, Baynam Gareth, Khoo Siew-Kim, Veenhoven Reinier H, van Heerbeek Niels, Zhang Guicheng, Laing Ingrid A, Rijkers Ger T, Goldblatt Jack, Sanders Elisabeth A M, Le Souëf Peter N
Abstract excerpt
BACKGROUND: Significant differences in immune responses upon vaccination have been described, suggesting genetics are important in determining the magnitude of vaccine responses. The interleukin (IL)-4 pathway, including IL-4, IL-13 and the IL-4 receptor alpha chain (IL-4 Ralpha), is central to humoral responses and therefore could have an impact on vaccine responsiveness. OBJECTIVE: To investigate whether single...
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