Article
Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses.
Clinical and vaccine immunology : CVI - 1 Aug 2006
Wiertsema S P, Khoo S-K, Baynam G, Veenhoven R H, Laing I A, Zielhuis G A, Rijkers G T, Goldblatt J, Lesouëf P N, Sanders E A M
Abstract excerpt
Innate immunity is of particular importance for protection against infection during early life, when adaptive immune responses are immature. CD14 plays key roles in innate immunity, including in defense against pathogens associated with otitis media, a major pediatric health care issue. The T allele of the CD14 C-159T polymorphism has been associated with increased serum CD14 levels. Our objective was to...
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