Article
Genetic Variants in the IL-4/IL-13 Pathway Influence Measles Vaccine Responses and Vaccine Failure in Children from Mozambique.
Viral immunology - 1 Sept 2017
Clifford Holly D, Hayden Catherine M, Khoo Siew-Kim, Naniche Denise, Mandomando Inacio M, Zhang Guicheng, Richmond Peter, Le Souëf Peter N
Abstract excerpt
Despite effective measles vaccines, measles still causes severe morbidity and mortality worldwide, particularly in developing countries. The Th2 pathway involving interleukin (IL)-4 and IL-13 cytokines, and their receptor IL-4Rα, play important roles in the Th1/Th2 balance and antibody production. A Th2 skewing of the cytokine milieu may affect vaccine responses. We investigated IL-4, IL-13, and IL-4Rα...
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