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Article

The IS10 antisense RNA blocks ribosome binding at the transposase translation initiation site.

The EMBO journal - 1 Apr 1990

Ma C, Simons R W

Abstract excerpt

Transposase (tnp) expression from insertion sequence IS10 is controlled, in part, by an antisense RNA, RNA-OUT, which pairs to the translation initiation region of the tnp mRNA, RNA-IN. Genetic experiments suggest that control occurs post-transcriptionally. Here, we present evidence that bears on the control mechanism. Specific ribosome binding at the tnp translation initiation site is demonstrated in vitro. Two...

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Identifiers

PMID: 1691097
DOI: 10.1002/j.1460-2075.1990.tb08235.x
PMCID: PMC551804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The IS10 antisense RNA blocks ribosome binding at the transposase translation initiation site.PMID 1691097Read ↗

IS10 antisense control in vivo is affected by mutations throughout the region of complementarity between the interacting RNAs.Semantic proximity Read ↗

Models for pairing of IS10 encoded antisense RNAs in vivo.Semantic proximity Read ↗

Control of translation by mRNA secondary structure: the importance of the kinetics of structure formation.Semantic proximity Read ↗

Preferential cis action of IS10 transposase depends upon its mode of synthesis.Semantic proximity Read ↗

Translation initiation of IS50R read-through transcripts.Semantic proximity Read ↗

Antisense RNAs in bacteria and their genetic elements.Semantic proximity Read ↗

Decay of the IS10 antisense RNA by 3' exoribonucleases: evidence that RNase II stabilizes RNA-OUT against PNPase attack.Semantic proximity Read ↗

IS10 mRNA stability and steady state levels in Escherichia coli: indirect effects of translation and role of rne function.Semantic proximity Read ↗

Identification, characterization, and variable expression of a naturally occurring inhibitor protein of IS1106 transposase in clinical isolates of Neisseria meningitidis.Semantic proximity Read ↗

Cis preference of the IS903 transposase is mediated by a combination of transposase instability and inefficient translation.Semantic proximity Read ↗

Evidence for a role of translational frameshifting in the expression of transposition activity of the bacterial insertion element IS1.Semantic proximity Read ↗

Escherichia coli translation initiation factor 3 discriminates the initiation codon in vivo.Semantic proximity Read ↗

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