Article
Decay of the IS10 antisense RNA by 3' exoribonucleases: evidence that RNase II stabilizes RNA-OUT against PNPase attack.
Molecular microbiology - 1 Sept 1994
Pepe C M, Maslesa-Galić S, Simons R W
Abstract excerpt
RNA-OUT, the 69-nucleotide antisense RNA that regulates Tn10/IS10 transposition folds into a simple stem-loop structure. The unusually high metabolic stability of RNA-OUT is dependent, in part, on the integrity of its stem-domain: mutations that disrupt stem-domain structure (Class II mutations) render RNA-OUT unstable, and restoration of structure restores stability. Indeed, there is a strong correlation between...
Topics
- Bacterial Proteins
- Base Sequence
- DNA Transposable Elements
- Exoribonucleases
- Gene Expression Regulation, Bacterial
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Nucleotidyltransferases
- Polyribonucleotide Nucleotidyltransferase