Article
Identification, characterization, and variable expression of a naturally occurring inhibitor protein of IS1106 transposase in clinical isolates of Neisseria meningitidis.
Infection and immunity - 1 Dec 2001
Salvatore P, Pagliarulo C, Colicchio R, Zecca P, Cantalupo G, Tredici M, Lavitola A, Bucci C, Bruni C B, Alifano P
Abstract excerpt
Transposition plays a role in the epidemiology and pathogenesis of Neisseria meningitidis. Insertion sequences are involved in reversible capsulation and insertional inactivation of virulence genes encoding outer membrane proteins. In this study, we have investigated and identified one way in which transposon IS1106 controls its own activity. We have characterized a naturally occurring protein (Tip) that inhibits...
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