Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies.

doi:10.1007/s10974-006-9086-1

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Article

Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies.

Journal of muscle research and cell motility - 1 Jan 2006

Dulhunty A F, Beard N A, Pouliquin P, Kimura T

Abstract excerpt

There are many mutations in the ryanodine receptor (RyR) Ca2+ release channel that are implicated in skeletal muscle disorders and cardiac arrhythmias. More than 80 mutations in the skeletal RyR1 have been identified and linked to malignant hyperthermia, central core disease or multi-minicore disease, while more than 40 mutations in the cardiac RyR2 lead to ventricular arrhythmias and sudden cardiac death in...

Topics

Amino Acid Sequence
Animals
Arrhythmias, Cardiac
Calcium
Calsequestrin
Homeostasis
Humans
Molecular Sequence Data
Muscle Cells
Muscular Diseases
Mutation
Peptides
Protein Binding
Protein Structure, Tertiary
Ryanodine Receptor Calcium Release Channel

Source

Open in PubMed

Identifiers

PMID: 16909197
DOI: 10.1007/s10974-006-9086-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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