Determination of the number of polypeptide subunits in a functional VDAC channel from Saccharomyces cerevisiae.

doi:10.1007/BF00769527

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Article

Determination of the number of polypeptide subunits in a functional VDAC channel from Saccharomyces cerevisiae.

Journal of bioenergetics and biomembranes - 1 Feb 1992

Peng S, Blachly-Dyson E, Colombini M, Forte M

Abstract excerpt

Genes encoding VDAC proteins containing specific site-directed amino acid alterations were introduced into wild-type Saccharomyces cerevisiae. The mutant VDAC proteins form channels with ion selectivities very different from that of the wild-type channel. Therefore, the resulting yeast strains ex...

Topics

Fungal Proteins
Ion Channels
Membrane Potentials
Membrane Proteins
Mitochondria
Mutation
Porins
Saccharomyces cerevisiae
Voltage-Dependent Anion Channels

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