Article
Large scale rearrangement of protein domains is associated with voltage gating of the VDAC channel.
Biophysical journal - 1 Apr 1992
Peng S, Blachly-Dyson E, Forte M, Colombini M
Abstract excerpt
The VDAC channel of the mitochondrial outer membrane is voltage-gated like the larger, more complex voltage-gated channels of the plasma membrane. However, VDAC is a low molecular weight (30 kDa), abundant protein, which is readily purified and reconstituted, making it an ideal system for analyzing the molecular basis for ion selectivity and voltage-gating. We have probed the VDAC channel by subjecting the cloned...
Topics
- Amino Acid Sequence
- Biophysical Phenomena
- Biophysics
- Electrochemistry
- Ion Channel Gating
- Ion Channels
- Membrane Proteins
- Mitochondria
- Molecular Sequence Data
- Mutation
- Porins