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Article

Mechanisms of neuropsychiatric lupus: The relative roles of the blood-cerebrospinal fluid barrier versus blood-brain barrier.

Journal of autoimmunity - 1 Jul 2018

Gelb Sivan, Stock Ariel D, Anzi Shira, Putterman Chaim, Ben-Zvi Ayal

Abstract excerpt

The pathogenesis of neuropsychiatric lupus (NPSLE) is believed to include the entry of circulating neuropathic antibodies to the brain via a pathologically permeable blood-brain barrier (BBB). Nevertheless, direct evidence of BBB pathology or mechanisms underlying BBB dysfunction is missing. Here, we examined BBB integrity in an established NPSLE mouse model (MRL/faslpr/lpr). Surprisingly, challenging the barrier...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29627289
DOI: 10.1016/j.jaut.2018.03.001
PMCID: PMC5994369

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