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Article

Cell culture models to investigate the selective vulnerability of motoneuronal mitochondria to familial ALS-linked G93ASOD1.

The European journal of neuroscience - 1 Jul 2006

Raimondi Andrea, Mangolini Alessandra, Rizzardini Milena, Tartari Silvia, Massari Silvia, Bendotti Caterina, Francolini Maura, Borgese Nica, Cantoni Lavinia, Pietrini Grazia

Abstract excerpt

Mitochondrial damage induced by superoxide dismutase (SOD1) mutants has been proposed to have a causative role in the selective degeneration of motoneurons in amyotrophic lateral sclerosis (ALS). In order to investigate the basis of the tissue specificity of mutant SOD1 we compared the effect of the continuous expression of wild-type or mutant (G93A) human SOD1 on mitochondrial morphology in the NSC-34...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microscopy, Electron, Transmission

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Source

Identifiers

PMID: 16903849
DOI: 10.1111/j.1460-9568.2006.04922.x

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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