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Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis

1 Jul 2002

Abstract excerpt

The molecular mechanisms by which mutations in the gene for Cu/Zn superoxide dismutase (SOD1) lead to the selective death of motor neurones in familial amyotrophic lateral sclerosis (FALS) remain incompletely understood. Previous evidence has indicated that mitochondrial abnormalities may develop during motor neurone injury, but several important questions remain unanswered. We have developed a cell culture model...

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PMID: 12077002
DOI: 10.1093/brain/awf167

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