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Article

Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding.

Journal of pharmacological sciences - 1 Jan 2008

Nagaoka Yuko, Ahmed Maruf, Hossain Murad, Bhuiyan Mohiuddin Ahmed, Ishiguro Masaji, Nakamura Takashi, Watanabe Masatomo, Nagatomo Takafumi

Abstract excerpt

Computer simulations of the human alpha(1d)-adrenergic receptor (alpha(1d)-AR) based on the crystal structure of rhodopsin have been combined with experimental site-directed mutagenesis to investigate the role of residues in the transmembrane domains in antagonist binding. Our results indicate that the amino acids Asp176 in the third transmembrane domain (TMD), Glu237 in TMD IV, and Ser258 in TMD V of...

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Identifiers

PMID: 18187928
DOI: 10.1254/jphs.fp0071412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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