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Article

Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas.

The Journal of pathology - 1 Nov 2006

Judson H, Stewart A, Leslie A, Pratt N R, Baty D U, Steele R J C, Carey F A

Abstract excerpt

Epigenetic mechanisms in carcinogenesis may have a significant role in the development of colorectal cancer. To investigate this phenomenon in early-stage disease, promoter methylation status in the tumour suppressor genes APC, MGMT, hMLH1, P14/P14ARF, and CDKN2A/P16 was investigated in 78 colorectal adenomas. These had previously been characterized for mutations of APC, KRAS, and TP53 genes and for chromosomal...

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Share to Adenoma
Share to DNA Modification Methylases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Genes, APC

Share to Genes, p16

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Share to MutL Protein Homolog 1

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 16902913
DOI: 10.1002/path.2044

Genes

APC
MGMT
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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