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Article

Cis and trans regulatory elements in NPHS2 promoter: implications in proteinuria and progression of renal diseases.

Kidney international - 1 Oct 2006

Di Duca M, Oleggini R, Sanna-Cherchi S, Pasquali L, Di Donato A, Parodi S, Bertelli R, Caridi G, Frasca G, Cerullo G, Amoroso A, Schena F P, Scolari F, Ghiggeri G M

Abstract excerpt

Podocin (NPHS2) expression in podocytes is associated with variable degrees of proteinuria and progression to renal failure in different glomerular diseases that suggests different expression profiles in NPHS2 promoter. Three functional polymorphisms in NPHS2 promoter (-51T, -116T, and -535 insCTTTTTT(3)) were found determining strong downregulation (-73, -59, and -82%, respectively) of the reporter gene...

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Source

Identifiers

PMID: 16900088
DOI: 10.1038/sj.ki.5001767

Genes

NPHS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cis and trans regulatory elements in NPHS2 promoter: implications in proteinuria and progression of renal diseases.PMID 16900088Read ↗

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