Article
Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome.
Kidney international - 1 Nov 2020
Jia Xiaoyuan, Yamamura Tomohiko, Gbadegesin Rasheed, McNulty Michelle T, Song Kyuyong, Nagano China, Hitomi Yuki, Lee Dongwon, Aiba Yoshihiro, Khor Seik-Soon, Ueno Kazuko, Kawai Yosuke, Nagasaki Masao, Noiri Eisei, Horinouchi Tomoko, Kaito Hiroshi, Hamada Riku, Okamoto Takayuki, Kamei Koichi, Kaku Yoshitsugu, Fujimaru Rika, Tanaka Ryojiro, Shima Yuko, Baek Jiwon, Kang Hee Gyung, Ha Il-Soo, Han Kyoung Hee, Yang Eun Mi, Abeyagunawardena Asiri, Lane Brandon, Chryst-Stangl Megan, Esezobor Christopher, Solarin Adaobi, Dossier Claire, Deschênes Georges, Vivarelli Marina, Debiec Hanna, Ishikura Kenji, Matsuo Masafumi, Nozu Kandai, Ronco Pierre, Cheong Hae Il, Sampson Matthew G, Tokunaga Katsushi, Iijima Kazumoto
Abstract excerpt
To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. Beyond known associations in the HLA-DR/DQ region, common variants in NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) and TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved genome-wide...
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