Article
Functional analysis of promoter mutations in the ACTN4 and SYNPO genes in focal segmental glomerulosclerosis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2010
Dai Shengchuan, Wang Zhaohui, Pan Xiaoxia, Wang Weiming, Chen Xiaonong, Ren Hong, Hao Cuilan, Han Bin, Chen Nan
Abstract excerpt
BACKGROUND: To investigate the promoter mutations of ACTN4 and SYNPO genes in patients with idiopathic focal segmental glomerulosclerosis (FSGS), and to provide functional analysis of these mutations in the role of FSGS occurrence. METHODS: The study consisted of 82 Chinese idiopathic FSGS patients (55 patients had nephrotic syndrome: NS) and 90 healthy individuals. Genomic DNA extracted from peripheral...
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