Article
Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma
2 Oct 2008
Abstract excerpt
BACKGROUND: Barrett's esophagus (BE) is the metaplastic replacement of squamous with columnar epithelium in the esophagus, as a result of reflux. It is the major risk factor for the development of esophageal adenocarcinoma (EAC). Methylation of CpG dinucleotides of normally unmethylated genes is associated with silencing of their expression, and is common in EAC. This study was designed to determine at what...